Legend Biotech US is looking for a Sr. Associate Scientist/Associate Scientist to join our team in Philadelphia, PA. This role supports early-stage development of engineered Lentiviral vectors by developing and executing analytical methods that enable candidate evaluation and selection. You will generate critical, decision-driving data across exploratory phases and partner closely with cross-functional stakeholders, including Quality, to ensure analytical readiness as programs advance toward impactful gene therapies at Legend Biotech.
What You'll Do
- Perform Lentiviral vector (LVV) functional titration through transduction and flow cytometry.
- Quantify LVV genetic payload concentration via dPCR.
- Determine LVV protein concentration via ligand binding assays (e.g., ELISA, MSD).
- Support method development, qualification, and technology transfer across internal teams.
- Prepare and deliver analytical technical reports, data summaries, and presentations.
- Enable strong cross-functional execution through clear communication and data delivery across internal and partner teams.
- Maintain an organized, compliant laboratory environment to ensure consistency, traceability, and data integrity.
- Troubleshoot routine assays using a data-driven root-cause approach, document results, and coordinate corrective actions with senior staff as needed.
What We're Looking For
- BS degree with 3+ years relevant industry experience; MS degree with 1+ year relevant industry experience; or PhD with 0+ years of relevant industry experience in biochemistry, virology, molecular biology, cell & gene therapy, or a related field.
- Working knowledge of cell biology, biochemistry, and molecular biology concepts, including basic kinetic principles relevant to assay performance.
- Demonstrated ability to execute routine wet-lab experiments with attention to detail, consistency, and reproducibility.
- Ability to analyze, interpret, and summarize experimental data and maintain accurate documentation and traceability.
- Clear written and verbal communication skills, including the ability to share results in reports, summaries, and presentations.
- Ability to work effectively with internal and cross-functional partners and respond to shifting priorities.
- Familiarity with good documentation practices and maintaining an organized lab environment to support data integrity and compliance expectations.
Nice to Have
- Strong hands-on experience with LVV analytical assays, including cell transduction, flow cytometry-based functional titer, and genetic payload quantification (dPCR/qPCR).
- Experience with ligand-binding assays for protein quantification and/or residual impurity testing.
- Prior exposure to method development/optimization, qualification, and technology transfer in a developmental environment.
- Familiarity with data integrity expectations and partnering with QC teams.
- Ability to troubleshoot analytical methods using a data-driven approach with appropriate escalation and documentation.
- Experience supporting lentiviral vector drug product characterization, including in vivo or translational studies.
- Comfortable working in a fast-paced environment, balancing short-term execution with longer-term assay/platform improvement.
Technical Stack
- Lentiviral vector (LVV) functional titration
- Flow cytometry
- dPCR
- qPCR
- ELISA
- MSD (ligand binding assays)
Team & Environment
You will be part of the R&D team at Legend Biotech, a company dedicated to treating, and one day curing, life-threatening diseases. We are building a culture where our people feel empowered, supported, and inspired to do their best work.
Benefits & Compensation
- Medical, dental, and vision insurance
- 401(k) retirement plan with a company match that vests fully on day one
- Eight (8) weeks of paid parental leave after three (3) months of employment
- Paid time off policy including vacation, personal time, sick time, floating holidays, and eleven (11) company holidays
- Flexible spending and health savings accounts
- Life and AD&D insurance
- Short- and long-term disability coverage
- Legal assistance
- Supplemental plans (pet, critical illness, accident, and hospital indemnity insurance)
- Commuter benefits
- Family planning and care resources
- Well-being initiatives
- Peer-to-peer recognition programs
Work Mode
This is a hybrid position based in Philadelphia, PA.
Legend Biotech US is an equal opportunity employer.
