Syngene is hiring a Senior Scientist - ADME to support the in vitro metabolism team within drug discovery and development for small molecules. This is a predominantly laboratory-based role focused on conducting high-quality ADME studies and managing multiple projects within agreed timelines.
What You'll Do
- Support the ADME in vitro metabolism team in drug discovery and development for small molecules.
- Conduct high-quality liver microsome and CYP inhibition assays to support ADME studies.
- Operate liquid handling systems and automation platforms with proficiency.
- Manage time and multi-task to meet the demand of high-volume wave 1 ADME assays and complete multiple projects within timelines.
- Contemporaneously record lab activities and experiments and maintain a high level of housekeeping.
- Adhere to all safety rules and maintain a safe workplace.
- Plan and execute in vitro metabolism assays with extensive expertise.
- Design and perform in vitro metabolism studies, including single-point inhibition, reversible CYP IC₅₀ inhibition, and TDI-IC₅₀ shift assays using human liver microsomes.
- Prepare SOPs and EOPs.
- Report executed studies without any noncompliance.
- Report study results clearly in cross-functional scientific meetings.
- Follow environment, health, and safety (EHS) requirements at all times in the workplace ensuring individual and lab/plant safety.
- Ensure environment, health, and safety (EHS) measures are imparted via training and adhered within the team.
What We're Looking For
- M Pharm in any pharmaceutical science or M Sc in biological science.
- M Pharm in pharmaceutical sciences or M Sc in biological science with foundational years of industrial experience in DMPK/ADME research.
- Comprehensive understanding of in vitro ADME assays and technical expertise in trouble shooting the assays.
- Good, demonstrated knowledge in software such as Microsoft Excel and GraphPad Prism.
- Demonstrated cross functional leadership capabilities.
- Demonstrate ability to be a team player.
- Commitment to deliver the study reports within the agreed timelines.
- Adaptability to changes in the dynamic lab environment.
- Communicate confidently with colleagues and collaborators in meetings and presentation of study reports and evidence of publications in peer-reviewed journals.
Nice to Have
- Experience with automation is desirable.
Team & Environment
This role is part of the Discovery Biology department.
Work Mode
This position is onsite in Hyderabad.
It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities.
