Gilead Sciences, Inc. is hiring a Principal Scientist, Medicinal and Structural Chemistry

Gilead Sciences, Inc., a research-based biopharmaceutical company working to discover transformative medicines for life-threatening diseases, is hiring a Principal Scientist, Medicinal and Structural Chemistry. In this role, you will maintain and further develop Gilead’s NMR facility to support the Small Molecule Drug Discovery organization, bridging the disciplines of NMR spectroscopy and medicinal chemistry to advance our drug discovery pipeline.

What You'll Do

• Further develop the strategy for NMR spectroscopy and enhance capabilities to include seamless data analysis workflows and quantitative NMR analysis.
• Maintain the existing NMR facility to ensure optimal performance and to support Gilead’s Medicinal Chemistry research organization.
• Obtain and interpret multidimensional NMR data of small molecules and provide detailed reports and insights on chemical structures and properties.
• Develop and optimize traditional and novel NMR methods for various applications.
• Maintain accurate and detailed records of all experiments, analyses, and results in accordance with industry standards and regulatory requirements.
• Provide training and technical support to junior staff and other team members on NMR techniques and instrument operation.
• Collaborate and communicate effectively with medicinal chemistry colleagues and cross-functional teams.

What We're Looking For

• Ph.D. in organic chemistry, or equivalent discipline with an emphasis in NMR techniques and methods, and 5+ years of experience.
• OR Master's in organic chemistry, or equivalent discipline with an emphasis in NMR techniques and methods, and 8+ years of experience.
• OR Bachelor's in organic chemistry, or equivalent discipline with an emphasis in NMR techniques and methods, and 10+ years of experience.

Nice to Have

• Strong knowledge and experience in NMR spectroscopy with proven applications in the pharmaceutical industry.
• Demonstrated ability to obtain and analyze NMR data to perform structure elucidation in a medicinal chemistry environment.
• Strong data processing and analysis skills including coding language for data analysis and database management.
• Comprehensive knowledge of Bruker NMR instrumentation and software, methodology and Mnova NMR software.
• Excellent troubleshooting skills and ability to develop and optimize analytical methods.
• Effective written and verbal communication skills, with the ability to present findings clearly and concisely.
• High level of accuracy and attention to detail in all aspects of work.
• Strong synthetic skills and a solid knowledge of modern organic synthesis techniques.
• Experience with latest NMR techniques to elucidate interactions between small molecules and their drug targets.
• Experience with NMR based fragment screening methods.
• Experience with the use of liquid handlers for NMR sample preparation.
• Experience conducting multi-step organic synthesis.
• Recent experience conducting parallel or automated synthesis.
• Knowledge of DMPK and ADME principles.

Technical Stack

• Bruker NMR instrumentation and software
• Mnova NMR software
• Coding language for data analysis and database management

Team & Environment

You will be part of Gilead’s Small Molecule Drug Discovery organization, supporting the Medicinal Chemistry research group.

Benefits & Compensation

• Compensation range: $195,670.00 - $253,220.00
• Company-sponsored medical, dental, vision, and life insurance plans.
• Paid time off.
• Discretionary annual bonus.
• Discretionary stock-based long-term incentives.

Gilead Sciences Inc. is committed to providing equal employment opportunities to all employees and applicants for employment, and is dedicated to fostering an inclusive work environment comprised of diverse perspectives, backgrounds, and experiences.