MBX Biosciences is hiring a Senior Scientist, Peptide Chemistry to join the research and development team. In this role, you will play a key part in the design, synthesis, purification, and characterization of novel peptide-based therapeutics, directly contributing to the advancement of our drug discovery pipeline.
What You'll Do
- Lead the design and execution of complex synthetic routes for the development of novel peptide-based compounds.
- Utilize advanced analytical techniques, such as HPLC, MS, NMR, and other spectroscopic methods, to characterize and validate the biophysical stability of synthesized peptides.
- Conduct thorough literature reviews and stay abreast of the latest developments in peptide chemistry and related fields.
- Collaborate with cross-functional teams to develop and optimize peptide-based drug candidates, contributing to the evaluation of structure-activity relationships and pharmacokinetic properties.
- Actively participate in the planning and implementation of research strategies, including the design of experimental protocols, data analysis, and interpretation to support project milestones.
- Mentor and provide guidance to other scientists.
- Contribute to the drafting of research reports, publications, and patent applications.
- Maintain a strong commitment to laboratory safety, adhering to established protocols and practices, and ensuring compliance with regulatory guidelines and industry standards.
- Uphold Good Laboratory Practices (GLP) and prioritize safety at all times.
What We're Looking For
- A BS, MS or Ph.D. in Organic Chemistry, Chemical Biology, or a related discipline with a focus on peptide chemistry.
- A minimum of 7+ years of relevant industry experience in peptide synthesis, purification, and characterization, preferably within a biotechnology or pharmaceutical research environment.
- Strong problem-solving skills with detailed understanding of “side reactions” related to peptide synthesis.
- Expert level peptide purification, isolation, and analytical skills.
- Proven expertise in the design and execution of complex synthetic strategies, as well as in-depth knowledge of modern peptide chemistry techniques and methodologies.
- Proven experience in building complex peptides with multiple modifications.
- Strong proficiency in utilizing analytical instruments, such as HPLC, MS, and other spectroscopic tools, for the characterization and analysis of peptide compounds.
- Experience with physical characterization of peptides such as size exclusion chromatography, fibrillation assay, peptide purity assessment.
- Strong technical problem-solving skills both independently and as part of a team.
- Demonstrated ability to work effectively in a collaborative team environment, with excellent communication skills and a track record of successful interdisciplinary collaboration.
- A strong publication record in reputable scientific journals and/or demonstrated ability to contribute to intellectual property development through patent applications or related activities.
Technical Stack
- HPLC, MS, NMR, Spectroscopic methods
- Size exclusion chromatography, Fibrillation assay, Peptide purity assessment
Team & Environment
Reporting to the Director of Chemistry. You will work closely across discovery chemistry and discovery biology, including partnerships with the CMC formulation group and the MBX Discovery Team.
MBX Biosciences is an Equal Opportunity Employer and is committed to treating all applicants fairly without discrimination. We welcome applications from all individuals, regardless of race, national origin, gender, age, physical characteristics, social origin, disability, union membership, religion, family status, pregnancy, sexual orientation, gender identity, gender expression or any unlawful criterion under applicable law.
