C4 Therapeutics is hiring a Senior Scientist for the Lead Discovery group. This role is responsible for developing, optimizing, and routinely running biochemical and biophysical assays to directly support small-molecule drug discovery and targeted protein degradation programs. You'll join a company dedicated to delivering on the promise of targeted protein degradation science to create a new generation of medicines.
What You'll Do
- Design, develop, and execute biochemical and biophysical assays, including protein binding (e.g., SPR) and functional activity assays, to support hit identification, SAR development, and lead optimization.
- Analyze and integrate results across multiple assay formats and discovery inputs to generate clear, program-relevant interpretation to help drive SAR decisions, compound prioritization, and next-step experimental strategy.
- Communicate results proactively and transparently to project teams, including interpretation, limitations, and recommended next experiments.
- Apply creative scientific thinking to troubleshoot assays, refine experimental approaches, and solve technical challenges while maintaining high standards for data quality and reproducibility.
- Operate as a strong team scientist while maintaining clear ownership of deliverables: prioritize effectively, execute with urgency, and follow through on commitments that support project goals.
- Support targeted protein degradation programs by applying biochemical and biophysical approaches that inform binding, mechanism, and compound progression.
- Demonstrate scientific leadership at the bench, independently designing and executing work, building leadership within the sub-functional area, and effectively influencing project direction through data and insight.
What We're Looking For
- A Ph.D. or equivalent in biochemistry, biophysics, or a closely related discipline.
- Minimum of six years of post-graduate experience in an academic or life science setting, showing progressive deepening of expertise and increased scientific leadership in biochemical and biophysical approaches to studying protein–ligand interactions, with demonstrated experience supporting small molecule discovery programs.
- Experience working effectively on multidisciplinary discovery teams, contributing insight and mentorship, as well as demonstrating requisite communication, organizational, and time-management skills, with a track record of clearly conveying data interpretation, limitations, and next steps with a high sense of personal accountability.
- Strong hands-on experience designing, developing, and executing robust biochemical and biophysical assays, including functional activity and binding-based methods, to enable hit identification, SAR development, and lead optimization.
- Proven ability to generate high-quality, reproducible data and integrate results across multiple assay formats to inform compound prioritization and experimental strategy.
- Enthusiasm for working in a fast-paced discovery environment, bringing creativity, rigor, and a strong passion for advancing transformative therapeutics.
Nice to Have
- Demonstrated experience in targeted protein degradation, with the ability to characterize heterobifunctional degraders and molecular glue molecules.
- Proven experience managing CRO partnerships to ensure timely delivery of high-quality data.
Technical Stack
- SPR (Surface Plasmon Resonance)
- Biochemical assays
- Biophysical assays
Team & Environment
You will be part of multidisciplinary discovery teams.
Benefits & Compensation
- Salary range: $157,817.00 - $174,429.00 annually
C4 Therapeutics is an Equal Opportunity Employer.
