Eikon Therapeutics is hiring a Scientist II, Cell Line Engineering and CRISPR Screening. You will leverage your expertise in cell line engineering and CRISPR screening to support target validation and functional genomics, accelerating the development of novel therapeutics.
What You'll Do
- Engineer and validate complex mammalian cell line models for discovery and screening using Landing Pad, CRISPR/Cas9, and lentiviral approaches.
- Design and execute pooled and arrayed CRISPR knockout and activation screens in disease-relevant cell lines.
- Develop high-throughput assays for phenotypic and functional characterization of engineered cell lines.
- Analyze CRISPR screen datasets using bioinformatics pipelines and integrate multi-omics data for mechanistic insights.
- Collaborate closely with medicinal chemistry, pharmacology, and computational biology teams to prioritize targets and biomarkers.
- Drive continuous improvement of experimental protocols, data quality control, and automation strategies.
- Document findings in lab notebooks and technical reports, contributing to regulatory filings and patents as needed.
- Provide scientific mentorship and training to junior team members and interns.
What We're Looking For
- Postdoc fellowship; or Ph.D. in cell biology, molecular biology, genetics, bioengineering, or related discipline plus 2 years of relevant experience; or Master's plus 12 years of relevant experience.
- 3+ years of experience in CRISPR genome editing, cell line engineering, and large-scale functional screening in a biotech or pharmaceutical setting.
- Proficiency in mammalian cell culture, viral transduction methods, and molecular biology techniques.
- Strong data analysis skills using R, Python, or relevant bioinformatics tools to interpret CRISPR screening results.
- Experience with NGS library prep and understanding of sequencing data quality metrics.
- Demonstrated problem-solving skills with ability to work independently and in cross-functional teams.
- Effective written and verbal communication skills for interacting with internal stakeholders and external collaborators.
Technical Stack
- CRISPR/Cas9
- Landing Pad
- Lentiviral approaches
- R
- Python
- Bioinformatics tools
- NGS library prep
Benefits & Compensation
- Compensation range: $133,000 to $145,350
- 401k plan with company matching
- Medical (premiums covered by Eikon at 95%), dental and vision insurance (premiums covered at 100%)
- Mental health and wellness benefits
- Weeklong summer and winter holiday shutdowns
- Generous paid time off and holiday policies
- Life/AD&D Insurance (premiums covered at 100%) and optional supplemental employee-paid life/AD&D policies
- Enhanced parental leave benefit
- Daily subsidized lunch program when on-site
Work Mode
This is an onsite position.
Eikon is proud to be an equal opportunity employer and will consider all qualified applicants for employment.
