Legend Biotech US is hiring a Quantitative Pharmacology Scientist to play a pivotal role in our mission to treat and cure life-threatening diseases. In this position, you will lead modeling and simulation efforts to support our gene and cell therapy portfolio, focusing on shaping clinical pharmacology strategies and driving model-informed drug development.
What You'll Do
- Lead QSP and popPK modeling activities across preclinical and clinical development stages.
- Develop and apply mechanistic models to understand disease pathways, drug mechanisms, and patient variability.
- Conduct simulations to support dose selection, trial design, and exposure-response analyses.
- Collaborate cross-functionally with R&D, clinical, regulatory, and biostatistics teams.
- Author and review clinical pharmacology sections of regulatory documents such as INDs and NDAs.
- Contribute to scientific publications and conference presentations.
What We're Looking For
- An MS, PhD, or Pharm D in Pharmaceutical Sciences, Clinical Pharmacology, Applied Mathematics, Biomedical Engineering, or a related quantitative discipline.
- 7+ years of experience with an MS degree or 3+ years with a PhD/Pharm D in quantitative pharmacology or pharmacometrics within pharmaceutical or CRO companies.
- Demonstrated expertise in QSP and popPK modeling, with proficiency in tools like NONMEM, R, MATLAB, or Monolix.
- Deep understanding of PK/PD principles, translational medicine, and the role of quantitative pharmacology in model-informed drug development.
- Proven ability to apply modeling and simulation to enable rational and efficient preclinical and clinical drug development.
- Familiarity with regulatory requirements and guidelines for clinical pharmacology.
- Strong execution ability, independent scientific research, logical thinking, and problem-solving skills.
- Clear written and oral communication skills, good team spirit, and good project management skills.
- A proven track record of scientific contributions through publications or presentations.
Nice to Have
- Prior cell and gene therapy experience.
Technical Stack
- NONMEM
- R
- MATLAB
- Monolix
Team & Environment
You will be part of the Research & Early Development team at Legend Biotech, a culture where people feel empowered, supported, and inspired to do their best work.
Benefits & Compensation
- Medical, dental, and vision insurance.
- 401(k) retirement plan with a company match that vests fully on day one.
- Eight (8) weeks of paid parental leave after three (3) months of employment.
- Paid time off including vacation, personal time, sick time, floating holidays, and eleven (11) company holidays.
- Flexible spending and health savings accounts.
- Life and AD&D insurance, and short- and long-term disability coverage.
- Legal assistance and supplemental plans for pet, critical illness, accident, and hospital indemnity.
- Commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition programs.
Work Mode
This role is a hybrid position based in Somerset, NJ.
Legend Biotech provides equal employment opportunities without regard to race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression, sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable law.
