Synolo Therapeutics is seeking a Principal Scientist, In Vivo Immunology to architect and execute in vivo pharmacology strategies across our multispecific biologics pipeline. You will serve as the subject matter expert, designing disease models, defining study endpoints, and driving data-driven decisions from discovery through development.
What You'll Do
- Lead in vivo pharmacology strategy across one or more discovery-stage programs, shaping experimental direction and program-level decisions.
- Design and refine disease-relevant murine models (e.g., syngeneic, humanized, immune-competent) to evaluate multispecific biologics.
- Design studies, define endpoints, and establish biomarker strategies to interrogate mechanism of action and therapeutic differentiation.
- Oversee and critically evaluate outsourced in vivo studies conducted at CROs, ensuring scientific rigor and data integrity.
- Lead hands-on in vivo and ex vivo experimentation, including dosing (IV, IP, SC), tumor inoculation, tissue collection, and immune profiling (flow cytometry, ELISA, MSD).
- Integrate and interpret complex in vivo and PK/PD datasets, translating findings into actionable recommendations for cross-functional teams and leadership.
- Establish best practices for experimental design, documentation, and data quality within the immunology function.
- Mentor and provide scientific guidance to junior team members.
What We're Looking For
- Demonstrated expertise in immunology and in vivo pharmacology, particularly in the evaluation of biologics.
- Proven experience designing and executing complex in vivo mouse models to interrogate immune function and therapeutic activity.
- Strong understanding of biologic modalities, including antibodies and multispecific constructs.
- Experience integrating PK analysis (e.g., WinNonlin) and bioanalytical assays into pharmacology studies.
- Deep hands-on experience in immune profiling techniques, including multi-parameter flow cytometry (FACS), immunohistochemistry (IHC), ELISA, and MSD.
- Proven ability to independently drive scientific strategy while collaborating effectively in cross-functional teams.
- Analytical and detail-oriented, with the ability to manage multiple priorities in a fast-paced environment.
- Excellent written and verbal communication skills, with the ability to clearly articulate complex scientific concepts.
- PhD, MS, or BS in Immuno-Oncology, Immunology, Cell Biology, or a related field. A minimum of 5 years of relevant industry experience is required for PhD candidates, 10 years for MS candidates, and 15 years for BS candidates.
Nice to Have
- Experience advancing biologic therapeutics from discovery through IND-enabling studies, including development of translational strategies that connect in vivo findings to clinical hypotheses.
- Prior experience building or scaling in vivo pharmacology capabilities within a growing biotech environment, influencing program direction and cross-functional decision-making.
Technical Stack
- WinNonlin
- Flow cytometry (FACS)
- ELISA
- MSD
- IHC
We are committed to fostering a diverse and inclusive work environment where all individuals are valued and treated with dignity. We believe that diversity drives innovation and strengthens our ability to make a meaningful impact through our work.
We are committed to being an equal opportunity employer who ensures that all qualified applicants receive equal consideration for employment without regard to neurodiversity, race/ethnicity, color, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.
