Orca Bio is seeking a Postdoctoral Fellow to conduct independent and collaborative research focused on liver injury, inflammation, and vascular dysfunction in MASH. You will join a dynamic research environment dedicated to advancing therapeutic strategies for liver disease.
What You'll Do
- Conduct independent and collaborative research to investigate mechanisms of liver injury, inflammation, and vascular dysfunction in MASH.
- Design and execute experiments using in vitro and in vivo models of lipotoxic liver disease.
- Perform advanced molecular and cellular biology techniques, including plasmid cloning, gene expression analysis, protein assays, and cell signaling studies.
- Isolate and characterize primary liver cells, including intrahepatic leukocytes, hepatocytes, and liver sinusoidal endothelial cells.
- Manage and perform rodent handling and interventions, including diet-induced MASH models and genetic or pharmacologic manipulations.
- Apply flow cytometry, immunohistochemistry, and immunofluorescence techniques to assess cell populations and pathological changes.
- Perform basic bioinformatic analysis (e.g., RNA-seq) and interpret complex datasets.
- Participate in manuscript preparation, presentations, and grant writing.
What We're Looking For
- Ph.D. in Physiology and Biomedical Engineering, Biochemistry and Molecular Biology, Immunology, Vascular Biology, or a related biomedical discipline.
- Demonstrated expertise in liver pathobiology and basic molecular and mechanistic techniques.
- Hands-on experience with animal handling, including approval and conduct of rodent studies.
- Proven ability with plasmid cloning, gene manipulation, and cell isolation procedures.
- Competence in basic bioinformatic data analysis (e.g., differential gene expression, pathway analysis).
- Solid background in immunology, particularly as related to inflammation and cellular crosstalk.
- Familiarity with vascular biology or endothelial cell function in organ pathology is highly desirable.
Nice to Have
- Use of omics approaches to understand tissue zonation and cell interactions.
- Experience in studying intercellular signaling.
- Strong written and oral communication skills suitable for presentations and publications.
Technical Stack
- Molecular and cellular biology techniques
- Plasmid cloning
- Gene expression analysis
- Protein assays
- Cell signaling studies
- Flow cytometry
- Immunohistochemistry
- Immunofluorescence
- Basic bioinformatic analysis (e.g., RNA-seq)
Benefits & Compensation
- Training in cutting-edge methodologies relevant to liver disease and immunometabolism.
- Collaborative environment at a leading academic medical research center.
- Opportunity to contribute to high-impact publications and translational research advancing therapeutic strategies for MASH.
- Medical: Multiple plan options.
- Dental: Delta Dental or reimbursement account for flexible coverage.
- Vision: Affordable plan with national network.
- Pre-Tax Savings: HSA and FSAs for eligible expenses.
- Retirement: Competitive retirement package to secure your future.
Work Mode
This is an onsite position based in Phoenix/Scottsdale, Arizona; Jacksonville, Florida; Rochester, Minnesota; Midwestern communities; or international locations.
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status.
