Eli Lilly Canada is seeking a Sr. Principal Process Engineer - Small Molecule to provide technical leadership for production operations. In this role, you will help build the organization, implement GMP-supporting systems, and shape the site culture during the project delivery and startup phase (2029–2030), leading into full-scale manufacturing.
What You'll Do
- Mentor process engineers in core engineering practices for oligonucleotide API supply.
- Promote data-driven decision-making using statistical methods and first principles.
- Support and review root cause analyses and technical documentation.
- Identify and address process knowledge gaps affecting equipment and process performance.
- Capture essential process knowledge, including material/energy balances, kinetics, and design basis.
- Maintain and support process safety foundations and hazard review activities.
- Ensure equipment qualification aligns with intended use and remains valid after changes.
- Integrate modeling and simulation to improve process understanding and control.
- Drive continuous improvement in equipment and processes within cross-functional teams.
- Lead or support tech transfer of new processes and unit operations.
- Guide development of user requirements, design reviews, and verification plans.
- Advise on return-to-service protocols following equipment interventions.
What We're Looking For
- Bachelor's Degree in Process, Chemical, Biochemical Engineering, or a related applicable STEM discipline.
- 5+ years of experience in API Manufacturing Unit Operations.
Nice to Have
- Experience with API chemical synthesis and biotech unit operations, including chromatography.
- Understanding of GMP production environments.
- Strong technical foundation in Chemical Engineering.
- Skill in analytical thinking and problem-solving.
- Ability to work independently and collaboratively within cross-functional teams.
- Capability to coach others to build technical expertise.
- Creativity in identifying improvements and proactivity in driving implementation.
- Experience mentoring through technical processes.
- Flexibility and adaptability to meet evolving business needs.
Team & Environment
You will be part of the leadership team for the startup of a new manufacturing site.
Benefits & Compensation
- Compensation: $64,500 - $167,200
- Eligibility for a company bonus.
- Eligibility to participate in a company-sponsored 401(k).
- Pension.
- Vacation benefits.
- Medical, dental, vision, and prescription drug benefits.
- Flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts).
- Life insurance and death benefits.
- Certain time off and leave of absence benefits.
- Well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs).
Work Mode
This is an onsite position at a new site location, which will be shared upon signing a confidentiality agreement.
Eli Lilly is proud to be an employer committed to equal opportunity.
