Crick is hiring a Senior Bioinformatician to work within Dr. Li’s Stem Cell and Cancer Biology laboratory. This role focuses on integrating functional CRISPR screens with single-cell and spatial transcriptomics to uncover mechanisms driving cell state rewiring and therapeutic resistance in cancer. The position is part of the Crick’s Bioinformatics & Biostatistics Scientific Technology Platform (STP), with dedicated time supporting the laboratory.
What You'll Do
- Work collaboratively across the Stem Cell and Cancer Biology laboratory to co-design experiments, formulate analysis plans, and interpret results.
- Perform standard and advanced analyses of high-dimensional, data-intensive and complex research questions using bioinformatics, biostatistics, machine learning and AI approaches.
- Empower biologists to understand their datasets, using training to enable data curiosity and develop analytical skills.
- Design innovative approaches for recurrent and novel projects, and deploy corresponding tools internally and beyond.
- Support data analysis of projects in the lab, including CRISPR screen sequencing, single-cell and spatial transcriptomics, ChIP-seq and ATAC-seq.
- Liaise with members of the REWIRE-CAN team to perform experiments and communicate data and results.
- Write and contribute to the preparation of scientific manuscripts, reports, presentations and records of experimental plans and results.
- Supervise and provide technical advice to more junior members of the team when appropriate.
- Participate and contribute to BABS’ and the Stem Cell and Cancer Biology laboratory’s groups by attending group meetings, and sharing knowledge and activities.
What We're Looking For
- PhD in Computational Cancer Biology or equivalent, or in the final stages of PhD submission.
- Evidence of applying computational/bioinformatic skill to address complex biological questions.
- Experience in single-cell RNA sequencing and spatial transcriptomic data analysis.
- Strong track record of research as evidenced by publications in referred journals.
- Strong written and oral communication skills as evidenced by data presentation at scientific meetings.
Nice to Have
- Experience in studying cellular plasticity using computational approach.
Team & Environment
This role is part of the Crick’s Bioinformatics & Biostatistics Scientific Technology Platform (STP), with time dedicated to Dr Li’s laboratory. You will report to Jean-Baptiste Cazier.
Benefits & Compensation
- Compensation from £53,025 with benefits, subject to skills and experience.
- Visas: Applicants for this role will be eligible for sponsorship to work in the UK.
- Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays.
- Pension Scheme: Defined contribution pension with employer contributions of up to 16%.
- Health & Well-being: 24/7 GP consultation services, Occupational health services and mental health support programs, Eye care vouchers and discounted healthcare plans.
- Work-Life Balance: Back-up care for dependents, Childcare support allowance, Annual leave purchase options, Crick Networks offering diverse groups’ support, community and inclusive social events.
- Perks: Discounted gym memberships, bike-to-work scheme, and shopping discounts, Subsidised on-site restaurant and social spaces for team interaction.
Work Mode
This role is onsite.
At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We are a Disability Confident: Committed employer.
