Allergan Aesthetics, an AbbVie company, is hiring a Scientist for the target lipid nanoparticle (tLNP) process development team. This role focuses on developing manufacturing processes for tLNP from purified mRNA into purified bulk drug product. You will scale up lab processes for pre-clinical, clinical, and commercial manufacturing.
What You'll Do
- Independently design, execute, and interpret critical experiments to advance understanding of unit operations like mRNA encapsulation, bioconjugation, and tangential flow filtration.
- Scale up unit operations from lab scale to commercial manufacturing batch size.
- Perform highly autonomous laboratory research or method development with minimal direction.
- Initiate new, scientifically meaningful areas of investigation that can be incorporated directly into a research or development program.
- Demonstrate high proficiency across a wide range of technologies relevant to tLNP process development.
- Formulate conclusions and design follow-on experiments based on multidisciplinary data.
- Act as primary author of publications, presentations, and regulatory documents, or as primary inventor on patents.
- Understand and adhere to corporate standards regarding code of conduct, safety, material handling, and GMP compliance.
- Provide direct mentorship to others.
What We're Looking For
- For Senior Scientist I: BS with 10+ years', MS with 8+ years', or PhD with 0+ years' industry experience.
- For Scientist II: BS with 7+ years' or MS with 5+ years' industry experience.
- Experience with LNP mixing technology in an academic lab, or industry experience with LNP drug product process development.
- For mRNA encapsulation, experience with systems other than microfluidics is required, such as impinging jet, coaxial jet, or multi-inlet vortex mixer.
- Thorough theoretical and practical understanding of mRNA encapsulation.
- Demonstrated ability to independently design, execute, and interpret critical experiments.
- Proven ability to learn, understand, and master new experimental techniques.
- Ability to multitask and work within timelines.
- Strong scientific writing and verbal communication skills.
Nice to Have
- Experience scaling up LNP processes to gram-scale mRNA or above is highly preferred.
- Experience with bioconjugation.
Technical Stack
- mRNA encapsulation
- Bioconjugation
- Tangential flow filtration
- LNP mixing technology
- Impinging jet, coaxial jet, and multi-inlet vortex mixer systems
Team & Environment
The tLNP process development team is part of the tLNP CMC team, a newly formed group under Biologics CMC, Development Sciences, R&D. The team works with mRNA process development, tLNP formulation, and analytical development teams, and collaborates with functions within Biologics CMC and Synthetic Molecule CMC departments.
Benefits & Compensation
- Paid time off including vacation, holidays, and sick leave
- Medical, dental, and vision insurance
- 401(k) plan
- Short-term incentive programs
AbbVie is an equal opportunity employer committed to operating with integrity, driving innovation, transforming lives, and serving our community.
