SF, United States of America Hybrid Full-time USD 180,000 – 230,000 / year

Probably Genetic is hiring a Senior Data Scientist

Responsibilities

  • Own the end-to-end development, validation, and operationalization of PG's predictive diagnostic AI models — from feature engineering through production deployment – that power program eligibility decisions and clinical decisions for patients
  • Run prospective testing experiments: apply diagnostic models to undiagnosed patients, coordinate testing, and track outcomes to continuously improve model performance
  • Build and maintain PG's synthetic patient data pipeline, a critical deliverable for our research programs, and key input to our own model development lifecycle
  • Optimize our patient intake experience using NLP and multimodal data analysis to determine which questions to ask, in what order, to maximize data quality and conversion
  • Own API usage and cost optimization across PG's AI stack, including prompt engineering, model evaluation, and ongoing performance monitoring
  • Conduct ad hoc strategic analyses that inform product prioritization, causality assessment, and generate customer-facing program insights
  • Establish MLOps infrastructure: model monitoring, drift detection, API observability, and lightweight but durable operational processes
  • Have the freedom to conduct blue sky research initiatives aimed at creating value from our data
  • Work with Data Engineering to build a robust, scalable data foundation that supports all of the above

Requirements

  • 7+ years of experience in data science, machine learning engineering, or a closely related field
  • Strong Python proficiency and fluency across the core data science stack: pandas, NumPy, scikit-learn, PySpark, and SQL
  • Demonstrated end-to-end ML experience: you have taken models from problem definition through feature engineering, validation, deployment, and monitoring in a production environment
  • Experience with NLP techniques and applying language models to real-world problems
  • Comfort with prompt engineering and evaluating external AI API performance (e.g., OpenAI)
  • A track record of operating with high ownership in lean, fast-moving environments where you have had to build structure as much as execute within it
  • Strong analytical communication skills — you can translate complex model outputs and data findings into clear, actionable narratives for technical and non-technical audiences alike

Nice to Have

  • Experience with Databricks or similar lakehouse/ML platform environments
  • Familiarity with synthetic data generation techniques
  • Domain knowledge in healthcare, rare disease, genomics, or clinical research
  • Experience with MLOps tooling and building observability infrastructure from scratch
  • Exposure to biopharma or insurance analytics use cases

Benefits

  • Competitive salaries
  • Comprehensive benefits
  • Meaningful early stage equity
  • An engaging and supportive team all on a mission to improve lives
  • Fair and equitable compensation with competitive early-stage equity grants
  • Generous Flexible Time off policy, that we actually use
  • Parental Leave Benefits (12 weeks for both birthing and non-birthing)
  • Hybrid, flexible work with high-trust and autonomy
  • A bright, inviting, pet-friendly office in Downtown SF near transit
  • A “work from anywhere” policy, up to 4 weeks a year
  • Regular team retreats in exciting destinations
  • Health Benefits including medical, dental, vision, therapy, FSA, and 401k
  • And so much more!

Work Arrangement

Hybrid — Downtown SF

Additional Information

  • Probably Genetic is committed to fostering a welcoming and inclusive work environment for people of all genders, sexuality, ethnicity, socioeconomic background and life experiences.
  • If you require specific accommodations as you interview or consider working with us, please let us know.
Required Skills
Data ScienceDatabricksClinical ResearchNatural Language Processing
About company
Probably Genetic

An AI platform that powers the research, diagnosis, and treatment of genetic diseases. Probably Genetic is building what others can't: the world's largest, most comprehensive dataset with the power to revolutionize care for patients with genetic diseases.

We partner with drug developers, clinical labs, and patient advocacy organizations to expand access to genetic counseling and testing. We offer reduced-cost genetic counseling and testing to help families access life-saving treatments, knowledge, and communities faster.

We collate datasets and build algorithms to collect and analyze patient data at scale, ultimately powering clinical research and accelerating diagnosis for rare genetic conditions.

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Job Details
Department Product
Category Data & ML
Posted 2 months ago