Twist Bioscience is hiring a Scientist - Tech Transfer

We are seeking a Scientist to join our Tech Transfer team, focused on advancing and scaling synthetic biology workflows across DNA-based and mammalian cell culture systems. This role sits at the interface of R&D and production, where you will drive the successful transfer of new products and processes into high-throughput manufacturing environments. You will play a key role in developing, optimizing, and troubleshooting workflows spanning molecular biology and mammalian cell culture systems, ensuring processes are robust, scalable, and production-ready. This includes hands-on experimental work, cross-functional collaboration, and enabling operational teams through training, technical guidance, and documentation. This is a highly collaborative role partnering with teams across operations, automation engineering, and bioinformatics to translate innovation into reliable production processes. A key component of this work will be designing processes with automation in mind, enabling deployment across a diverse suite of liquid handling platforms to support scalable and standardized manufacturing. We are looking for someone who combines strong experimental rigor with practical problem-solving, and who is equally comfortable working at the bench and thinking strategically about process improvement. Experience across both DNA technologies (e.g., NGS, cloning) and mammalian cell culture/protein expression systems is highly valued. If you enjoy working in a fast-paced, multidisciplinary environment where you can directly impact how products are built and delivered at scale, this role offers broad exposure to cutting-edge synthetic biology platforms and technologies. Key Responsibilities - Design and execute experiments to develop, optimize, and scale production workflows for synthetic biology products, including DNA and mammalian cell-based protein expression systems - Drive process improvements by analyzing complex datasets and translating findings into actionable changes across workflows - Lead technical transfer of new products and processes into production, ensuring robustness, reproducibility, and scalability - Author and maintain technical documentation, including SOPs, validation protocols, and training materials to support manufacturing teams - Act as a technical subject matter expert, representing R&D/PD in cross-functional meetings and contributing to project strategy and decision-making - Collaborate cross-functionally with operations, automation, and bioinformatics teams to troubleshoot issues and implement solutions - Apply scientific literature and domain expertise to inform experimental design, process development, and strategic direction - Maintain clear and accurate documentation of experimental work and results using electronic lab notebooks - Mentor and train team members and operators on newly developed processes and workflows Qualifications And Required Skills - PhD in Molecular Biology, Biochemistry, or related field; or Master’s with 2–5+ years of industry experience; or Bachelor’s with 5+ years of relevant experience - Strong foundation in molecular biology techniques, including DNA/RNA purification, PCR/qPCR, and molecular cloning - Hands-on experience developing and optimizing mammalian cell culture systems for protein expression (e.g., HEK, CHO) - Experience designing expression constructs and optimizing systems for yield, solubility, and activity across host platforms - Proven ability to develop and optimize upstream and downstream workflows, including transfection and protein purification strategies - Demonstrated experience in experimental design, data analysis, troubleshooting, and method development in complex biological systems - Strong attention to detail and ability to translate experimental outcomes into scalable process improvements - Solid scientific judgment and ability to independently drive technical decisions Preferred Skills - Experience with next-generation sequencing (NGS) workflows, library preparation, and/or data analysis - Familiarity with high-throughput workflows and laboratory automation systems (e.g., liquid handlers) - Programming or data analysis experience (e.g., Python, SQL, JSON) for handling large datasets - Proven ability to manage multiple priorities in a fast-paced environment - Strong collaboration and communication skills, with experience working across multidisciplinary teams - Experience mentoring, training, or onboarding team members - Demonstrated problem-solving skills and a proactive, solution-oriented mindset - Self-motivated with a commitment to continuous learning and staying current with scientific advancements