Apply on company website Cambridge, MA USA On-site Full-time USD 188,000 – 257,500 / year

Flagship Pioneering is hiring a Principal Software Engineer - Agentic Platform

Responsibilities

  • Lead full lifecycle development of the agentic platform, transitioning research prototypes into robust, production-ready systems with a focus on long-term workflow orchestration.
  • Design and implement scalable, fault-tolerant systems for workflow management, evaluation, and event-driven processing to ensure reliability and performance.
  • Establish clear SDK interfaces and API specifications that separate model development from agent outputs, enabling independent iteration while maintaining system stability.
  • Develop infrastructure-as-code templates using AWS CDK and Terraform, and convert experimental AI models into standardized, reusable platform components.
  • Ensure the platform maintains high efficiency in resource usage and cost while meeting strict performance and accuracy requirements for scientific applications.
  • Define and promote best practices for agent architecture, deployment strategies, and code quality to guide platform-wide technical standards.
  • Collaborate with modeling, agent, and product teams to coordinate integrations, manage dependencies, and support engineering mentorship across disciplines.

Responsibilities

  • Own the agentic platform end to end, from research prototype to production, building the durable orchestration layer for long-running, multi-stage scientific workflows.
  • Architect workflow orchestration, evaluation frameworks, and event-driven distributed systems that deliver scale, resilience, and reliability.
  • Define SDK abstractions and API contracts between model and agent outputs and downstream consumers, decoupling rapid model iteration from product stability and reducing integration friction across teams.
  • Deliver infrastructure-as-code reference implementations (AWS CDK, Terraform, containerized services) and transform exploratory AI proof-of-concepts into hardened, reusable patterns adopted across product domains.
  • Own platform cost-efficiency and scalability while preserving the performance and accuracy that our experiments and end users require.
  • Explore and template agent design and deployment patterns, and set technical standards, code quality, and architectural direction for the platform.
  • Partner across teams (modeling and agent teams, product) to align on integration points, dependency timelines, and delivery, and mentor engineers and scientists.
Job Details
Location Cambridge, MA USA
Work mode On-site
Employment Full-time
Salary USD 188,000 – 257,500 / year
Department Pioneering Intelligence
Category DevOps & SRE
Posted 4 days ago
Application On company website
About company
Flagship Pioneering logo

We invent and build companies that change the world. Our process begins with seemingly unreasonable “what-if” questions that push beyond current knowledge, encouraging teams to dream big and leap boldly into alternative futures.

Through rigorous science and systematic entrepreneurship, we navigate to transformational outcomes. We have founded more than 120 companies focused on bioplatforms and patentable white spaces, designed to generate multiple products that secure a healthier and more sustainable future.

Our unique model enables bold ideas to be conceived, created, and capitalized in-house. We combine scientific creativity, technological know-how, professional capital management, and executive leadership in a single, integrated institution.

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